Sam and Dean hit the road to help an old friend, but it appears that their luck may have finally run out and they are the ones who may be in need of rescue.
Dean and Sam press their luck in a winner-takes-all game of pool. Meanwhile, Castiel hunts down a would-be murderer, but not for reasons one might think.
Charlie contacts Sam and Dean after she finds the Book of the Damned - which could help eliminate the mark of Cain; Castiel and Metatron look for Castiel's grace.
While investigating a strange murder, Sam and Dean discover the killer has the same tattoo as those from the Styne family; Castiel plays referee when Charlie and Rowena...